Are you on supplemental Iodine?
If not, you should be unless you are eating a lot of seaweed or nori.
See below for a very nice review of what Iodine does and why you need it.
I recommend all of my patients take about 6 mg per day. That is safe and will provide you with enough so that your body’s Iodine levels are in good range.
Have a great week.
Dr. David I Minkoff, M.D.
FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, June 12, 2017
The Need for Iodine Supplementation
by Wojciech Rychlik, Ph.D.
(OMNS, June 12, 2017) Feeling tired, having low energy or depression, gaining weight, memory problems, having dry skin, dry mouth or immune system issues? There is good chance your body needs iodine supplementation. Why iodine? Because this essential to human health element has been singled out as dangerous, for several obscure reasons, and it has been gradually eliminated from our diet, and even worse, replaced by its antagonist, bromine. This trend has been termed, iodophobia (1). It is a cause of widely occurring hypothyroidism in many developed countries.
Iodine: how much?
Iodine deficiency is associated with (2,3,4):
- fibrocystic breast disease leading to breast cancer, stomach cancer,
- goiter (enlarged thyroid)
- mental issues from reduced alertness, lowered IQ, autism to cretinism, lack of iodine for the fetus leads to cretinism, and in milder cases to autism and ADHD
- slow metabolism, leading to tiredness, sluggishness, fatigue, apathy, depression and insomnia,
- inability to produce saliva, dry skin and lack of sweating,
- lack of optimal detoxification, especially of bromides, fluorides and heavy metals
- sensitivity to temperature changes, cold hands and feet,
- muscle pain, fibrosis, fibromyalgia,
- erectile dysfunction, infertility and miscarriages, low sex drive,
- high blood pressure, increased incidence of heart attacks and strokes
The Food and Agriculture Organization of the United Nations has published probable safe upper limits for dietary intake of iodine (5). They range from 150 micrograms (mcg) per kilogram (kg) per day in newborn infants to 30mcg/kg/day in adults. That is 2 milligrams (2,000 micrograms) daily for a 146-pound adult. The safe upper limit is higher during pregnancy and lactation (40 mcg/kg/day).
Treatments for hypothyroidism
The simplest method to deal with an underactive thyroid is proper supplementation with iodine, called orthoiodosupplementation. If the thyroid is damaged, then supplementation with thyroid hormones, thyroxine (T4) and triiodothyronine (T3, the main biologically active hormone) may be necessary. Supplementation (6). with these hormones should be done under close supervision of a medical professional. However, supplementation with inorganic iodine is generally much safer, as the body “knows” how much T4 and T3 need to make. There are also drugs that change physiology of iodine metabolism, but this subject is beyond the scope of this article. Pharmaceutical companies pressure doctors to avoid inexpensive orthoiodosupplementation, so you won’t likely get a prescription for inexpensive Lugol’s solution from a mainstream practitioner.
One caveat to supplementation with iodine is the autoimmune illness called Hashimoto’s disease, or chronic lymphocytic thyroiditis, which is one of the potential causes of hypothyroidism. Unfortunately, when hypothyroidism is diagnosed, the possibility that Hashimoto’s disease underlies this condition has not always been properly tested. Therefore, Hashimoto’s disease has often been mis-diagnosed. Doctors usually treat this condition with hormone replacement therapy, and some believe that excessive iodine intake may trigger it in susceptible people (7). Always ask your doctor if iodine supplements are right for you.
History of iodine usage and “iodophobia”
This subject has been covered in detail by Dr. Guy E. Abraham (8,9,10). The iodine element was discovered in 1811 by B. Courtois. In 1850-53 A. Chatin noted that goiter and cretinism are rare in geological zones rich in iodine and frequent where iodine is in short supply, and that goiter can be prevented by iodine supplementation. In 1895 E. Baumann proposed that iodine is the active element in the thyroid gland.
By the time Bauman identified large concentrations of iodine in the thyroid gland in 1895, pharmaceutical and apothecary preparations containing iodine, excluding thyroid extracts, were widely used as a panacea.
To quote Kelley: (11) “The variety of diseases for which iodine was prescribed in the early years is astonishing – paralysis, chorea, scrofula, lacrimal fistula, deafness, distortions of the spine, hip-joint disease, syphilis, acute inflammation, gout, gangrene, dropsy, carbuncles, whitlow, chilblains, burns, scalds, lupus, croup, catarrh, asthma, ulcers, and bronchitis – to mention only a few. Indeed, tincture of iodine, iodoform, or one of the iodides, was applied to almost every case that resisted the ordinary routine of practice; and between 1820 and 1840 there appeared a remarkable series of essays and monographs testifying to the extraordinary benefits to be achieved by this new and potent remedy.”
Unfortunately, these monographs have virtually disappeared from US medical libraries. In the mid-1800’s, iodine treatments of some diseases called for ingestion of gram (1,000 mg) amounts per day. However, most treatments were from 5 to 50 mg daily. The recommended daily amount of iodine by Dr. G. E. Abraham is 0.1-0.3 ml Lugol containing 12.5-37.5 mg elemental iodine. This is the amount of iodine needed for whole body sufficiency, based on a recently reported iodine/iodide-loading test (12). Thyroid gland sufficiency for iodide is achieved with a lower dose.
The first iodophobic authority emerged in early 1900’s. Prof. T. Kochler reported that he suffered from overactive thyroid following ingestion of iodide (just a single individual case, not a statistical research study!) Despite this, the number of applications grew. In an International Index published in 1956, and devoted exclusively to iodine pharmaceuticals, no less than 1,700 approved iodine-containing products were listed. In 1948 Wolff and Chaikoff published that a serum inorganic iodide level at a concentration of 1 µM blocks (one micromolar) the synthesis of thyroid hormones, resulting in hypothyroidism and goiter in rats. But this conclusion was erroneous as they even did not measure thyroid hormones in the rats studied, and of course, hypothyroidism and goiter were not observed in those rats. Many organic forms of iodinated drugs were quite poisonous. Unfortunately, medical establishment did not make a distinction between organic and inorganic forms of iodine, and iodophobia became more popular.
Decades ago, iodine was added to bread so that one slice contained 150 mcg of iodine (the current recommended daily allowance). In the 1980s, bromine replaced iodine in bread. Since bromide is an antagonist to iodine (it is goitrogenic), it worsened iodine deficiency in the USA. Moreover, a big push to remove salt from our diet (the only grocery item still supplemented with iodine) exacerbated the problem. The only developed nation that resisted iodophobia is Japan, statistically the healthiest and longest living nation on the planet. Their average daily consumption of iodine is around 5 mg, with various reports ranging from 1 to 18 mg. In a study of reported daily iodine intake versus total number of clinical symptoms, an intake of approximately 1 mg per day correlated with the lowest number of reported symptoms, that is, the highest level of health (13). Recent popularization of bromides in our food supplies likely increased this amount.
According to Dr. Abraham, (14) “proper amounts of iodine in the food supply should be considered one of a nation’s greatest assets. Removing iodine from the food supply is a major mistake. Supplying a daily intake of iodine sufficient for the whole body (100-400 times the RDA) gives protection against goitrogens and radioactive iodine/iodide fallout; improves immune functions, resulting in an adequate defense system against infection; decreases singlet oxygen formation which is the major cause of oxidative damage to DNA and macromolecules, resulting in an anticarcinogenic effect in every organ; results in a detoxifying effect by increasing urinary excretion of the toxic metals lead, mercury, cadmium, and aluminum, as well as the goitrogens fluoride and bromide; normalizes hormone receptor functions resulting in improved response to thyroid hormones both endogenous and exogenous; and results in better control of blood sugar in diabetic patients; stabilizes cardiac rhythm, obviating the need for the toxic sustained release form of iodine, amiodarone; and normalizes blood pressure without medication in hypertensive patients. Iodine deficiency is the major cause of cognitive impairment, worldwide.”
The iodine-cancer connection
The body requires iodine to metabolize both omega-3 and omega-6 fatty acids. A substance called delta-iodolactone, a derivative of arachidonic acid, which is produced in the thyroid gland and breast tissue, prostate, colon, and the nervous system, is a regulator of a process called cellular apoptosis (“cell death”). Ascorbic acid is required to stimulate intracellular hydrogen peroxide synthesis that, in turn, provides the energy to make iodine free radicals necessary for this reaction. When the level of delta-iodolactone is high enough, the process of apoptosis can then kill cancer cells.(15)
Unfortunately, the recommended daily allowance (RDA) for iodine – about 150 mcg per day – will not allow delta-iodolactone to be efficiently formed in the thyroid gland. The thyroid requires higher iodine concentrations to efficiently produce it. Researchers have found that 100 times the RDA amount of iodine is optimal to produce delta-iodolactone. That equates to taking about 15 mg of iodine per day (15,16). These findings are important because they imply that there are some biochemical reactions that require much larger amounts of iodine than the current RDA. The mechanism by which delta-iodolactone induces cell death may be an important pathway for curing some types of cancer.
Forms of iodine
Inorganic iodine exists in 6 oxidative states, from -1 to +7. The most reduced form (with most electrons) is iodide (I-); an example is potassium iodide. The diatomic form of elemental iodine I2, has no electrical charge. Monoatomic iodine also has no electrical charge, but is unstable and highly reactive (free radical, labeled as an I with a dot, I* ). It can be produced by exposing I2 to ultraviolet light. Electric and magnetic fields won’t do it, as is sometimes incorrectly suggested. More oxidized forms of iodine are: hypoiodite (I+1), iodite (I+3), iodate (I+5), and periodate (I+7). The body’s metabolism may convert (reduce) these forms to biochemically available iodide, but at the cost of depleting its antioxidants. All forms of positively charged iodine are relatively poisonous, with established lethal doses (LD50) in the range of 35 to 2100 mg/kg. Elemental iodine (I2) and iodides (I-) are non-poisonous. However, a bad “antiseptic” non-culinary taste of iodine (I2) suggests to our senses that this is not so good choice for supplementation.
Despite that adverse taste, almost all the research on iodine supplementation has been done using Lugol’s Solution (17). The original solution is called 5% Lugol’s Iodine, but in reality it consists of 12.5% iodide/iodine or (I-/[I3]-) ions. Two drops of Lugol’s Solution (0.1 ml) contain 12.5 mg iodine/iodide mix. Iodine tablets that are a solid form of Lugol’s solution, were created to mask the taste and make the doses more precise for dietary supplementation.
I should mention a few points about Edgar Cayce’s atomidine. This famous visionary wrote several articles about the best form of iodine supplement (18). Some claim that this was iodine trichloride, but that cannot be true as this compound is toxic by ingestion and damaging to mucous membranes. It decomposes to ICl and poisonous gas Cl2 at 77 degrees C and also in water at room temperature (19). Most likely Cayce’s atomidine was simply a 1% iodine solution (I2) in 95% ethanol. I am surprised that there are educated people, even medical doctors who claim that “elemental monoatomic iodine” preparations (Atomidine, Nascent Iodine etc.) are the best forms of iodine supplements. May be it has something to do with efficient marketing? Elemental Iodine (I2) is soluble in glycerin. Replacement of ethanol with glycerol indeed makes these supplements more consumption-friendly, so they are sold by some vendors as superior products to Cayce’s ethanol-formulated one. Personally, I think glycerol-based I2 supplements are inferior to iodides; however, they are excellent antiseptics.
To defend the validity of Cayce’s vision, in thyroid, I- ion and amino acid tyrosine react through a short intermediate step by forming monoatomic I* free radical (selenium and hydrogen peroxide are involved) to make monoiodotyrosine. Diiodotyrosine is formed analogical way, and finally, two of these molecules combine to produce thyroxine. All those steps are carried by the enzyme thyroid peroxidase, which is normally attached to the protein thyroglobulin. So, yes, monoatomic iodine I* exists in human bodies, and it directly reacts with tyrosine, but no, it wouldn’t be healthy to consume iodine free radicals as their high reactivity would prevent safe transport throughout the body.
In the mid 1930’s the thyroid hormone thyroxine became available on the market. This was a blessing for people who had damaged their thyroid. Unfortunately, doctors started to prescribe this hormone to just about anybody with hypothyroidism, thinking that they can control better thyroid hormone levels than our bodies can. And, the “iodine is iodine, no matter what form” mentality became a dangerous trend, because most medical professionals do not fully appreciate the difference between the raw nutrient (iodine) and its product (hormone).
The pharmaceutical industry came up with lots of organic forms of iodine (NB: organic, meaning that iodine is bound to a carbon-atom-containing molecule and NOT meaning it’s grown in a pesticide-free environment), all relatively toxic and certainly not to be used without strict medical supervision. Only inorganic forms of iodine, I- and I2, are safe for supplementation (20,21). Further, high doses of these supplements should still be supervised by your doctor.
Iodine plays critical role in human metabolism. Many researchers believe the RDA value of 150 mcg for iodine is too low, especially when this element is commonly substituted with competing element bromine. Therefore, the main use of iodine in dietary supplementation is to enable optimal thyroid function. There are a number of medical conditions where iodine is either essential or helpful. For best results, iodine/iodide should be supplemented with selenium, magnesium, copper (there is usually enough of it in tap water as copper is widely used in plumbing), vitamin B2 (riboflavin) and B3 (niacin). Ask your doctor before taking any iodine supplements, especially if you are on medications.
Elemental iodine (I2) is antibacterial and antifungal, so iodine or iodine/iodide solutions are commonly used topically to sterilize wounds, or internally to fight infections, such as vaginitis and sore throat, and also to sanitize drinking water. Because iodine is antibacterial, drinking it may cause friendly bacterial flora to suffer and result in diarrhea and stomach cramps (the same applies to Lugol’s solution, but to a lesser extent as it contains iodides as well).
Ingestion of iodides prevents the incorporation of destructive radioactive iodine into the body (mainly by the thyroid) in case of nuclear accidents. It also may help flushing already incorporated radioactive iodine from the thyroid, although too much iodine inhibits secretion of T4/T3 from the gland.
Overdosing any of the iodine supplements can lead to swollen salivary glands, metallic aftertaste and skin rash and itching (that are usually due to rapid process of detoxification from heavy metals fluorides and bromides), faster heartbeat or palpitations and diarrhea. When supplementation is stopped, these symptoms will usually disappear quickly, often within one day. Iodine stabilizes thyroid hormone production, so it is an adaptogen, but in rare cases, such as acquired allergy to iodine (Hashimoto’s disease), it may actually misbalance it. In some cases, iodine supplementation can cause hypothyroidism, so it’s important to get checked by your doctor to make sure that your thyroid function is not worsened by supplementation. Some authors advising caution are Alan Christianson (22), Jeffrey Dach, (23) and Alan Gaby (24). Testing of levels of thyroid hormones along with testing and supplementation of mineral nutrients such as selenium, zinc, copper, magnesium calcium, and other trace minerals may prevent problems in cases where high doses of iodine/iodide might tend to cause Hashimoto’s disease. (23)
Inorganic iodine availability
The most common form of iodine supplement is Lugol’s solution (17). The original solution contains 5% of iodine and 10% iodide. Solid pill forms of Lugol’s solution are sold under several brand names. Potassium iodide (KI), my favorite iodine supplement, is available as tablets as well. Various products with kelp or other seaweed extracts contain iodides as well. Check the label when you buy as some of them are very diluted.
It is difficult to find inexpensive elemental iodine (I2) solution in alcohol. You can buy iodine crystals online and make the proper solution by yourself very easily (using either alcohol or glycerol). The monoatomic iodine concept is simply a marketing gimmick that has been created to inflate the price several fold. Note that if the monoatomic claims were really true, few would really want to drink free radicals, the only monoatomic form that exists. Iodine free radicals are not transported freely in our bodies because they are too reactive. Elemental iodine preparations, including iodine dissolved in glycerol, may be helpful products for external antiseptic use rather than a supplement.
Another form of iodine supplement includes a mixture of algae and thyroid extract in glycerin, water and ethanol. This is likely not harmful because it contains T3 and T4 only in very small amounts, and the recommended serving size is also small. Other complex formulae that contain elemental iodine are a useful antiseptic, but not a good supplement. Iodine trichloride should be avoided as a supplement because it is too toxic.(19)
The established RDA allowance for iodine (150 mcg/day) is inadequate for many individuals. In order to maintain optimum health, adults need 2-5 mg of iodide daily. Actually, this is in line with the upper safe limit of dietary intake of iodine established by FAO (30 mcg/kg/day). In case of a dysfunctional thyroid or other illnesses, such as fibrocystic breast disease or cancer, 15-50 mg daily may be needed. Ask your doctor about the alternatives to hormone therapy or taking iodine-containing organic drugs, because inexpensive orthoiodosupplementation would usually not be his/her first choice.
The best and safest form of iodine supplementation for a healthy adult is iodide. Iodides are naturally produced in larger quantities by various seaweeds.
Please consult your doctor about iodine supplementation, as in your particular case it may be contraindicated.
2. Dommisse J. MD Best Kept Secret (2009)
4. Hamza RT1, Hewedi DH, Sallam MT. (2013) Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity. Arch Med Res. 44(7):555-61. http://www.ncbi.nlm.nih.gov/pubmed/24120386
8. Abraham GE. The History of Iodine in Medicine Part I: From Discovery to Essentiality. http://optimox.com/pics/Iodine/IOD-14/PUB_14.htm
9. Abraham GE. The historical background of the Iodine Project.
11. Kelly FC. “Iodine in medicine and pharmacy since its discovery , 1811-1961.” Proc R Soc Med, 1961; 54:831-836. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869599/
12. Abraham GE. “The safe and effective implementation of orthoiodosupplementation in medical practice.” The Original Internist, 2004; 11(1):17-36. http://www.hakalalabs.com
13. Fallon Morell S. The Great Iodine Debate (2009) The WestonA. Price Foundation, http://www.westonaprice.org/modern-diseases/the-great-iodine-debate/
14. Abraham GE. The Wolff-Chaikoff Effect: Crying Wolf?
15. Brownstein D. The Cancer-Iodine Connection, (2015) http://www.newsmax.com/Health/Dr-Brownstein/iodine-cancer-cell-death-fish-oil/2015/06/10/id/649877/
16. 6-Iodolactone, key mediator of antitumoral properties of iodine, M. Nava-Villalba, C. Aceves, (2014) Prostaglandins & Other Lipid Mediators 112, 27-33. https://www.researchgate.net/publication/263856609_6-Iodolactone_key_mediator_of_antitumoral_properties_of_iodine
17. Bacteriological Analytical Manual, R40 Lugol’s Iodine Solution (2001), http://www.fda.gov/Food/FoodScienceResearch/LaboratoryMethods/ucm062245.htm
18. Review of Atomidine, International Wellness Directory, http://www.mnwelldir.org/docs/reviews/atomidine.htm
19. Abraham GE. The historical background of the Iodine Project
20. Abraham GE and Brownstein D. A Rebuttal of Dr. Gaby’s Editorial on Iodine. (2005) Townsend Letter, The Examiner of Alternative Medicine, http://www.townsendletter.com/Oct2005/gabyrebuttal1005.htm
21. Christianson A. http://www.integrativehealthcare.com/why-i-discourage-high-dose-iodine/
22. Dach J. http://jeffreydachmd.com/iodine_is_safe
“I am at the beginning of my fifth week of treatment and I feel crazy good. When I started here 5 weeks ago, I was in pain all over and my gut was so bad I was doubled over. Now I have zero pain. I also had no energy but after all my treatments I feel like I have a whole new life! Thank you.”
The Many Advantages of Chelation
I thought of waiting to discuss Chelation in February (Heart Health month) but decided to address it now. Why withhold a beautiful pearl until the last minute?
When I think of Chelation (pronounced Chee-la-shun), I think of what older mentors in Integrative Medicine used as treatment for many health issues. It was the one treatment that these brilliant physicians offered to their patients that they cared so much about and wanted to see get better.
So it’s time to resurrect this “Old Faithful” and give it the accolades it deserves!!!
One way of resurrecting this old friend, is bringing forth the TACT study. TACT stands for “The Trial to Access Chelation Therapy.” This was a study that clarified a long conflict between conventional and mainstream physicians treating Coronary artery disease. The study was completed in 2012 and the results were published in 2013.
The study had 1708 patients, who had a previous Myocardial Infarction (heart attack) and were at least 50 years old. 603 of these patients also had Diabetes.
There were four groups that received different treatments:
- Active chelation + vitamins and minerals
- Active chelation + placebo vitamins and minerals
- Placebo chelation + vitamins and minerals
- Placebo chelation + placebo vitamins and minerals.
Let’s first look at Cardiovascular Disease. There was a 26% reduction in cardiac events with chelation, vitamins and minerals compared to the placebo group that received placebo chelation, vitamins and minerals. A reduction of26% is a big exciting number when you are looking at cardiovascular events. The head of the TACT study was a cardiologist. He was so excited about the results that he published it in prominent medical journals and faculties. Due to the enthusiasm, he received funding to continue phase 2 of the TACT study, called TACT-2 which is focusing on Diabetic post-MI patients.
In looking at Diabetes, this subgroup performed even better than the group as a whole. There was an impressive 43% reduction in deaths of people who had diabetes. With this positive result, the TACT 2 study has started and if the results prove to be the same, it will most likely become a standard of care.
Another goal of the TACT study, was to assess if oral high dose vitamins and minerals reduced cardiovascular injury. It was found that the participants who had chelation and oral vitamins did better than the participants who had none.
Although heavy metal removal is proven to be effective with chelation, this was not examined in the TACT study. Most Integrative Providers know the importance of toxic metals, its burden on the body and the importance of removal.
We all know the effects of the toxicities that accumulate in the body due to our toxic environment. However, many people don’t realize that if you ask your physician to test your metals and they do a common blood test, the likelihood of it showing anything are slim.
One would need to pursue it further and request a heavy metal Chelation Challenge test. It is a procedure where you get administered a chelation agent, hopefully intravenous as this is the most accurate. Then the patient collects their urine for the next 6 hours. This will reflect what is known as the “body burden” of metals in the body. The metals will lay dormant in the organs, bone, brain and tissue. If someone really wants to tackle and address this with true efficacy, then this is the method I would suggest.
To your health,
Jennifer Baer, ARNP
Osteoporosis is also known as brittle bone disease. It has become a major health concern for many American’s. It affects far more women than men. Although both sexes can suffer the progressive loss of bone density that leads to fractures of the wrists, spine or hips. Bone is not a static tissue. It is constantly being broken down in a process known as resorption and rebuilt throughout our lives. If less bone is being made than is disappearing, it becomes porous and easily broken.
Osteoporosis is also called the silent epidemic. It often makes its presence known when a person incurs a surprise fracture after a minor fall. Visible symptoms are loss of height and the development of a stoop or “dowagers hump” as the skeleton weakens and shrinks.
Up to one in four women are believed to be at risk of osteoporosis, which is thought to be closely linked to a fall in hormone levels, vitamin and mineral deficiencies or lack of sufficient dietary protein.
Dr. Springer Talks About GERD
“Thank you for all your help in ascertaining the root of my health problem. It is unfortunate that most doctors these days don’t uncover the root and work to fix it. They only want to manage the symptoms. It was a pleasure working with you.”
Sincerely, Lynn. A.
- Did you know that seventy million people in the USA have heart disease?
- Did you know that heart disease is the chief cause of death among American women of all ages?
- Did you know that deaths from cardiovascular disease are twice as common as deaths from cancer in the USA?
- Did you know that you are at a much greater risk of heart disease if you have high cholesterol, high blood pressure, a weight problem, are a smoker, have diabetes or a family history of heart disease?
Heart disease is America’s number one killer, and that statistic is no different in Tampa Bay.
Several risk factors are:
- Tobacco smoke
- Use of estrogens
- Excessive alcohol use
- High blood cholesterol
- High blood pressure
- Physical inactivity
- Obesity or overweight
Looking on the preventative side, what can the citizens of Tampa Bay do to maintain a healthy heart?
There are many steps you can take.
- Keep your blood pressure under control
- Keep your blood cholesterol under control
- Stop smoking
- Eat a healthy diet with lots of fresh organic fruit and vegetables
- Get plenty of regular exercise
- Keep your weight under control
LifeWorks is happy to announce that we are now accepting CareCredit cards. For many people CareCredit can provide an easier way of financing you and your family’s healthcare needs*. For more information go to carecredit.com
*Subject to credit approval.