Ozone Therapy


Syringe used for the prolozone iv treatment

History of Prolotherapy Treatment

Prolotherapy was first discovered in the middle 1950’s by an orthopedic surgeon named George Hackett. Dr. Hackett noticed that many people who had chronic pain, especially pain around the joints including the low back, neck, hips and knee, had pain stemming from the ligaments and tendons that held those tissues together. In many cases the pain was blamed on the joints themselves or degeneration of the cartilage, or osteoarthritis.

Dr. Hackett discovered that as the ligament is a band of fibrous tissue that holds bones together, just like a rubber band, it can become overstretched. The resulting laxity can cause severe pain as bones rub together or muscles are overworked as they tighten in an attempt to stabilize bones.

What is a Prolotherapy Injection?

Prolotherapy is a treatment where a solution called a proliferant.  (A proliferant is something that makes something grow or expand.)

The proliferant is a natural substance that is injected directly into the site where the weakened ligament attaches to the bone.

Traditional formulas include ingredients such as dextrose, saline, sarapin. It will also include a local anesthetic such as procaine or lidocaine, to minimize any discomfort of the injection.

How Prolotherapy Injections Work in the Body

These injections trigger the body’s own skeletal system to grow new and healthy collagen which then properly stabilizes the bones and joints, relieving various musculoskeletal pain and stiffness.

Once injected into the ligament, it triggers a healing response. In animal experiments, this healing response has shown to increase the size of the thickness of the ligament by as much as 40%.

What is Prolotherapy Good For?

Prolotherapy is one of the treatments of choice for chronic pain. It is used to treat

  • chronic joint pain
  • degenerative arthritis
  • low back pain
  • mid-back pain including degenerative disc disease
  • sacroiliac joint issues
  • torn ligaments
  • cartilage
  • joint issues
  • carpal tunnel syndrome
  • neck pain
  • knee pain & meniscal tears
  • wrist or hand pain
  • osteoarthritis
  • shoulder pain including rotator cuff tears
  • elbow pain including golfers or tennis elbow
  • foot pain including plantar fasciitis
  • ankle pain or instability, hypermobility
  • osteitis pubis
  • IT band syndrome
  • piriformis syndrome
  • temporal mandibular joint syndrome (TMJ)
  • and many other musculoskeletal pains or injuries

Prolotherapy Injection Testimonials

Patient climbing stairs. Prolozone helped my knees

No More Daily Knee Brace*

This is a voluntary recommendation to use Karima Redouan A.P.R.N.; a Board Certified Family Nurse Practitioner for Prolozone Therapy. My name is Neal G. and I am a retired ...

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Patient receiving prolozone injections for joint pains


Dr Minkoff, I have had much success with your ozone treatments, they are miraculous. I had tried cortisone shots and many other treatments but nothing worked as well as prolo...

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What to Expect

Prolotherapy is a technique which requires no surgery and has no long term negative side-effect. Our patients find Prolotherapy extremely valuable.

85% to 90% of people with low back pain can get complete relief with Prolotherapy treatment.

In most cases, between 1-6 treatments are required, separated by approximately 3-4 weeks.

Over the course of treatment, people feel gradually decreasing pain and improvement of function.

Try Prolotherapy

Many Tampa Bay residents have found amazing pain relief from Prolotherapy.

It’s a very easy and convenient treatment. It’s fast and results can be astonishing.

It might be just the treatment you need.

If you’re interested in learning more, call us at 727-466-6789 for an appointment.

Or make an online request.

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