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In 1995, Dr. Minkoff's wife became ill and her physicians couldn't find what was wrong. Not accepting their "no hope" conclusion, Dr. Minkoff went on a search to help her which led him out of emergency medicine into complementary and alternative medicine to find the answers. In the process he gained expertise in Biological medicine, heavy metal detoxification, anti-aging medicine, hormone replacement therapy, functional medicine, energy medicine, neural and prolotherapy, homeopathy and optimum nutrition. He studied under the masters in each of these disciplines until he became an expert in his own right. The answers he found were soon in demand when others learned of his wife’s return to good health. In response to this, he and his wife, Sue Minkoff RN established Lifeworks Wellness Center in 1997 and it quickly became one of the most comprehensive complementary and alternative medicine clinics in the U.S.