Prolozone Therapy

Prolozone Therapy is a powerful regenerative treatment that reduces pain, improves joint function, and stimulates the body’s natural healing processes. The name “Prolozone” comes from a combination of “ozone” and the Latin word proli, meaning “to regenerate or rebuild.” It also refers to proliferation, as the therapy promotes the growth and repair of new ligament and connective tissue in weakened or damaged areas.

Prolozone is an advanced injection therapy that works similarly to Prolotherapy but with one key enhancement: the use of ozone. Ozone is a highly reactive form of oxygen that, when injected into a joint capsule, stimulates fibroblasts—the cells responsible for repairing and rebuilding connective tissue. This leads to faster healing and often greater long-term results than traditional Prolotherapy alone.

Prolozone helps repair and tighten lax ligaments, strengthen partially torn tissues, and interrupt the pain/inflammation cycle. As circulation improves, blood flow increases, delivering oxygen and nutrients to the affected area. This creates a healing environment within the joint, leading to reduced pain, improved mobility, and enhanced joint stability.

What sets Prolozone apart is its potential to correct the underlying cause of pain, rather than simply masking symptoms. In many cases, this results in long-lasting or even permanent relief. Studies and clinical experience show that 75–85% of chronic pain sufferers experience significant, lasting improvement—often becoming permanently pain-free.

Dr. David Minkoff Explains Prolozone Therapy

Watch Dr. Minkoff explain how Prolozone therapy works, its benefits and the fast relief obtainable with Prolozone therapy.

Do You Have Back, Hip or Joint Pain?

Are you suffering from low back pain, mid back pain, shoulder pain or elbow pain? You’re not alone. The usual course of treatment for these types of pain are surgery, pain killers, anti-inflammatory drugs and cortisone shots. While some of these solutions may offer temporary relief, they do not treat the underlying cause of the issue. Also, many of these treatments when used frequently, have negative side effects.

Common Conditions that Respond Well to Prolozone Therapy

Prolozone Rebuilds Joints & Heals Damaged Areas Naturally

Prolozone Therapy is a non-surgical solution for joint and ligament damage that works by injecting a combination of ozone gas and collagen-stimulating compounds directly into affected tissues. This approach encourages the reconstruction of weakened ligaments, tendons, and cartilage, providing long-term relief from chronic joint pain and instability—without surgery or extended downtime.

Unlike conventional treatments that simply manage symptoms, Prolozone addresses the root cause of joint degeneration by restoring strength, structure, and function to compromised connective tissues. This makes it an ideal therapy for individuals with chronic musculoskeletal pain, joint stiffness, or past injuries that never fully healed.

Understanding Why Joints and Ligaments Degenerate

Ligaments function as the supportive “cables” of the body, anchoring bones together and stabilizing joints. When these ligaments are injured—whether through trauma, overuse, or wear and tear—they rarely return to their original condition on their own. The primary reason is their limited blood supply, which slows healing and often leads to incomplete tissue repair.

To make matters worse, ligaments are richly innervated with pain-sensing nerves, which is why even small injuries can cause persistent discomfort and a reduced range of motion. As weakened ligaments fail to stabilize the joint properly, surrounding tissues such as tendons, cartilage, and muscles are forced to compensate, often leading to a cascade of mechanical imbalances and further degeneration.

Over time, continued stress on the joint creates abnormal shearing and torsional forces, which stretch ligaments and pull them away from the bone’s surface (the periosteum). The body responds by laying down new bone in the form of osteophytes (bone spurs)—hallmarks of degenerative arthritis. These structural changes reduce joint mobility and increase strain on surrounding muscles, worsening pain and dysfunction.

Prolozone’s Role in Recovery

By delivering oxygen-rich compounds directly into damaged tissues, Prolozone helps halt this degenerative cycle and promotes the regeneration of healthy, functional connective tissue. As ligaments and joint structures are rebuilt, stability improves, pain decreases, and range of motion is restored—allowing patients to return to the activities they love with greater ease and comfort.

Prolozone Therapy Success Stories!

Arthritic Hip Pain Relief with Prolozone!

Our beloved patient Florence, who turned 100 in 2014 was told by her orthopedic doctor that she had so much arthritis there was nothing he could and that she would have to live with the pain. She disagreed! She researched and found out about Prolozone therapy and then came to LifeWorks Wellness Center. A few Prolozone treatments later, she achieved major pain relief and she’s now back to her spritely self again!

Back Pain Healed

“I have suffered from acute back pain on and off for 25 years and recently it really flared up to the point where I could not walk without a cane. Bending and moving were excruciatingly painful. Since I have a very physical job as a construction contractor, it also prevented me from working. Previously, when my back has been bad I have visited chiropractors but since I’m now a patient of LifeWorks, I called Tamora to ask her advice. She said I should see Dr. Minkoff and have some prolozone therapy. It was a new one on me but I have great faith in LifeWorks, so I thought I would give it a try. When I entered Dr. Minkoff’s room I could barely walk or stand straight. When I left 20 minutes later, I was standing upright and the pain was significantly less. Almost immediately I was able to do some light work, and now after only three sessions I am back at work as normal. I am really impressed by this therapy and would recommend it to anyone in pain. Evidently, it doesn’t just help back issues – one of the LifeWorks’ staff told me she was having it for wrist pain. What I would say about this therapy is that while other treatments help to ‘manage’ the pain, prolozone therapy seems to ‘heal’ the source of the pain. Great job, Dr. Minkoff and LifeWorks!”   Greg. L.

I Can Finally Sleep Pain Free

Dear Dr. Minkoff, I just want to thank you for helping me get some relief. I feel like a different woman today! I don’t hurt at all & I actually got a good night’s sleep last night without any pain or pain medicine! That’s the first time in quite a while that I can say that. So, I just wanted to let you know how much better I feel & how thankful for your help & treatment. You’re an angel!  Thank you. D.M.

These Ozone Treatments are Miraculous!

Dr Minkoff, I have had much success with your ozone treatments, they are miraculous. I had tried cortisone shots and many other treatments but nothing worked as well as prolozone. The pain was much reduced and more successful than anything I have tried. I am thankful to you and your clinic for this wonderful success.  PLD

A Huge Difference After Only One Treatment

Prolozone is the BEST thing ever! Wow! What a huge difference it made after only one treatment, I had an immediate result. My right shoulder was scheduled for surgery and I didn’t like that. So I tried an alternative method first. I’m so glad I did because surgery “good bye!” NOT necessary at all. I have no pain and already a huge increase in range of motion. I need less sleep and still feel completely energized. I had a feeling that this O3 – Ozone should help me and fought hard to be able to get this treatment and now it totally paid off!!! IT REALLY, REALLY WORKS! Fantastic, miraculous results.   Antje. V

Read more Prolozone Patient Testimonials here!

Got Chronic Pain? Try Prolozone!

If you are living with chronic pain, Prolozone Therapy could help you. We are the #1 Prolozone clinic in the Tampa Bay area. We treat a variety of patients, from high performance athletes, to weekend warriors, to everyday people who are suffering from new or old injuries which are limiting their activity levels or just causing annoying chronic pain.

If you’re sick and tired of suffering from chronic joint pain and are looking for alternatives to invasive surgery, you owe it to yourself to try prolozone.

Call us today at (727) 466-6789 to find out more information or to book an appointment or feel free to inquire online.